Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents

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Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents.

AIM The present study was performed to investigate acute and subchronic oral toxicity of Ferula assa-foetida gum (28 days) in Sprague Dawley rats. MATERIALS AND METHODS Acute oral administration of F. assa-foetida was done as a single bolus dose up to 5 g/kg in mice and subchronic toxicity study for 28 days was done by oral administration at doses of 0 (control) and 250 mg/kg in Sprague Dawle...

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Double edged effect of gum-resin of ferula assa-foetida on lifespan of neurons

OBJECTIVE(S) Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specific markers β-Tubulin III and MAP2. After establishment of neuronal differenti...

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Antileishmanial activity of Ferula assa-foetida oleo gum resin against Leishmania major: An in vitro study

BACKGROUND In Ayurveda, asafetida is introduced as a valuable remedy for flatulence, hysteria, nervous disorders, whooping cough, pneumonia and bronchitis in children and also considered as an aphrodisiac agent. Presently, Leishmaniasis is common in most countries of the world and is a serious health problem in the world. Some plant medicines and natural products have a new candidate for treatm...

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Antinociceptive effect of Ferula assa-foetida oleo-gum-resin in mice

Ferula assa-foetida L. is distributed throughout central Asia and Mediterranean area and grows wildly in Iran and Afghanistan. Asafoetida is an oleo-gum-resin that is the exudates of the roots of Ferula assa-foetida and some other Ferula species. In Iranian traditional medicine, asafoetida is considered to be sedative, analgesic, carminative, antispasmodic, diuretic, antihelmintic, emmenagogue ...

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Acute and Subchronic Toxicity Assessment of Aerial Parts of Ferula persica in Female Mice

Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...

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ژورنال

عنوان ژورنال: Veterinary World

سال: 2015

ISSN: 0972-8988,2231-0916

DOI: 10.14202/vetworld.2015.584-589